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3DL6

Crystal Structure of the A287F/S290G Active Site Mutant of TS-DHFR from Cryptosporidium hominis

Summary for 3DL6
Entry DOI10.2210/pdb3dl6/pdb
Related2OIP 3DL5
DescriptorDihydrofolate reductase, DHFR, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, ... (6 entities in total)
Functional Keywordsenzyme active site mutant, enzyme-ligand complex, oxidoreductase
Biological sourceCryptosporidium hominis
Total number of polymer chains5
Total formula weight311415.37
Authors
Martucci, W.E.,Vargo, M.A.,Anderson, K.S. (deposition date: 2008-06-26, release date: 2008-08-19, Last modification date: 2023-08-30)
Primary citationMartucci, W.E.,Vargo, M.A.,Anderson, K.S.
Explaining an unusually fast parasitic enzyme: folate tail-binding residues dictate substrate positioning and catalysis in Cryptosporidium hominis thymidylate synthase.
Biochemistry, 47:8902-8911, 2008
Cited by
PubMed: 18672899
DOI: 10.1021/bi800466z
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.25 Å)
Structure validation

217705

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