3DL5
Crystal Structure of the A287F Active Site Mutant of TS-DHFR from Cryptosporidium hominis
Summary for 3DL5
| Entry DOI | 10.2210/pdb3dl5/pdb |
| Related | 2OIP 3DL6 |
| Descriptor | Dihydrofolate reductase, DHFR, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, ... (6 entities in total) |
| Functional Keywords | enzyme active site mutant, enzyme-ligand complex, oxidoreductase |
| Biological source | Cryptosporidium hominis |
| Total number of polymer chains | 5 |
| Total formula weight | 311565.49 |
| Authors | Vargo, M.A.,Martucci, W.E.,Anderson, K.S. (deposition date: 2008-06-26, release date: 2008-08-19, Last modification date: 2023-08-30) |
| Primary citation | Martucci, W.E.,Vargo, M.A.,Anderson, K.S. Explaining an unusually fast parasitic enzyme: folate tail-binding residues dictate substrate positioning and catalysis in Cryptosporidium hominis thymidylate synthase. Biochemistry, 47:8902-8911, 2008 Cited by PubMed: 18672899DOI: 10.1021/bi800466z PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.74 Å) |
Structure validation
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