3DL5
Crystal Structure of the A287F Active Site Mutant of TS-DHFR from Cryptosporidium hominis
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E | Dihydrofolate reductase, DHFR | polymer | 521 | 60338.6 | 5 | UniProt (Q5CGA3) In PDB | Cryptosporidium hominis | |
| 2 | A, B, C, D, E | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE | non-polymer | 308.2 | 5 | Chemie (UMP) | |||
| 3 | A, B, C, D, E | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID | non-polymer | 477.5 | 5 | Chemie (CB3) | |||
| 4 | A, B, C, D, E | DIHYDROFOLIC ACID | non-polymer | 443.4 | 5 | Chemie (DHF) | |||
| 5 | A, B, C, D, E | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 5 | Chemie (NDP) | |||
| 6 | water | water | 18.0 | 445 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E: 1 - 521 (UniProt: Q5CGA3)
| PDB | External Database | Details |
|---|---|---|
| Phe 287 | Ala 287 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 301693.1 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 9872.4 | |
| All* | Total formula weight | 311565.5 |
