3DKO

Complex between the kinase domain of human ephrin type-a receptor 7 (epha7) and inhibitor alw-ii-49-7

Summary for 3DKO

• Entry DOI: 10.2210/pdb3dko/pdb
• Related: 2REI
• Descriptor: Ephrin type-A receptor 7, 5-[(2-methyl-5-{[3-(trifluoromethyl)phenyl]carbamoyl}phenyl)amino]pyridine-3-carboxamide (3 entities in total)
• Functional Keywords: atp-binding, kinase, nucleotide-binding, receptor, transferase, phosphorylation, transmembrane, tyrosine-protein kinase, alternative splicing, glycoprotein, inhibitor, structural genomics consortium, sgc, membrane, phosphoprotein, polymorphism, nppsfa, national project on protein structural and functional analyses
• Biological source: Homo sapiens (Human)
• Cellular location: Cell membrane ; Single-pass type I membrane protein : Q15375
• Total number of polymer chains: 1
• Total formula weight: 36653.91

Authors

Walker, J.R.,Syeda, F.,Gray, N.,Butler-Cole, C.,Bountra, C.,Wolkstrom, M.,Arrowsmith, C.H.,Edwards, A.M.,Bochkarev, A.,Dhe-Paganon, S.,Structural Genomics Consortium (SGC) (deposition date: 2008-06-25, release date: 2008-08-19, Last modification date: 2023-08-30)

• Primary citation: Walker, J.R.,Syeda, F.,Gray, N.,Butler-Cole, C.,Bountra, C.,Wolkstrom, M.,Arrowsmith, C.H.,Edwards, A.M.,Bochkarev, A.,Dhe-Paganon, S.; Kinase domain of human ephrin type-a receptor 7 (epha7) in complex with ALW-II-49-7; To be Published,

Experimental method

X-RAY DIFFRACTION (2 Å)