3DKK

Aged Form of Human Butyrylcholinesterase Inhibited by Tabun

Summary for 3DKK

Related3DJY 3DL4 3DL7 2C0P 2C0Q
DescriptorCholinesterase, N-ACETYL-D-GLUCOSAMINE, BETA-L-FUCOSE, ... (7 entities in total)
Functional Keywordshydrolase, tabun, organophosphate, aging, disease mutation, glycoprotein, serine esterase
Biological sourceHomo sapiens (human)
Cellular locationSecreted P06276
Total number of polymer chains1
Total molecular weight62272.65
Authors
Nachon, F.,Carletti, E. (deposition date: 2008-06-25, release date: 2008-12-02, Last modification date: 2011-07-13)
Primary citation
Carletti, E.,Li, H.,Li, B.,Ekstrom, F.,Nicolet, Y.,Loiodice, M.,Gillon, E.,Froment, M.T.,Lockridge, O.,Schopfer, L.M.,Masson, P.,Nachon, F.
Aging of Cholinesterases Phosphylated by Tabun Proceeds through O-Dealkylation.
J.Am.Chem.Soc., 130:16011-16020, 2008
PubMed: 18975951 (PDB entries with the same primary citation)
DOI: 10.1021/ja804941z
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.31 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.247101.3%6.4%3.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution