3DJI

Crystal Structure of Macrophage Migration Inhibitory Factor Bound to an Acetaminophen Dimer Derived from NAPQI

Summary for 3DJI

• Entry DOI: 10.2210/pdb3dji/pdb
• Related: 1GD0 1MIF 3CE4 3DJH
• Descriptor: Macrophage migration inhibitory factor, CHLORIDE ION, N,N'-(6,6'-dihydroxybiphenyl-3,3'-diyl)diacetamide, ... (4 entities in total)
• Functional Keywords: homotrimer, acetaminophen dimer, cytokine, inflammatory response, isomerase, phosphoprotein
• Biological source: Homo sapiens
• Cellular location: Secreted : P14174
• Total number of polymer chains: 6
• Total formula weight: 74962.44

Authors

Crichlow, G.V.,Lolis, E. (deposition date: 2008-06-23, release date: 2008-12-23, Last modification date: 2023-08-30)

• Primary citation: Crichlow, G.V.,Lubetsky, J.B.,Leng, L.,Bucala, R.,Lolis, E.J.; Structural and kinetic analyses of macrophage migration inhibitory factor active site interactions.; Biochemistry, 48:132-139, 2009; PubMed: 19090677; DOI: 10.1021/bi8014423

Experimental method

X-RAY DIFFRACTION (1.95 Å)