3DJ8

Synthesis of (2S)-2-amino-7,8-epoxyoctanoic acid and structure of its metal-bridging complex with human arginase I

Summary for 3DJ8

• Entry DOI: 10.2210/pdb3dj8/pdb
• Related: 2ZAV 2aeb
• Descriptor: Arginase-1, MANGANESE (II) ION, 6-[(2R)-oxiran-2-yl]-L-norleucine, ... (4 entities in total)
• Functional Keywords: epoxide binding, manganese cluster, arginine metabolism, disease mutation, hydrolase, manganese, metal-binding, phosphoprotein, urea cycle
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P05089
• Total number of polymer chains: 2
• Total formula weight: 70125.93

Authors

Di Costanzo, L.,Christianson, D.W. (deposition date: 2008-06-22, release date: 2008-07-08, Last modification date: 2023-11-01)

Primary citation

Zakharian, T.Y.,Di Costanzo, L.,Christianson, D.W.
Synthesis of (2S)-2-amino-7,8-epoxyoctanoic acid and structure of its metal-bridging complex with human arginase I
Org.Biomol.Chem., 6:3240-3243, 2008

PubMed Abstract: The synthesis of (2S)-2-amino-7,8-epoxyoctanoic acid is reported along with the X-ray crystal structure of its complex with human arginase I, revealing unique coordination interactions with two manganese ions in the enzyme active site.

PubMed: 18802628
DOI: 10.1039/b811797g

Experimental method

X-RAY DIFFRACTION (1.51 Å)