3DI6

HIV-1 RT with pyridazinone non-nucleoside inhibitor

Summary for 3DI6
DescriptorReverse transcriptase/ribonuclease H, p51 RT, 6-(4-chloro-2-fluoro-3-phenoxybenzyl)pyridazin-3(2H)-one, ... (4 entities in total)
Functional Keywordshiv, rt, reverse transcriptase, transferase rna-directed dna polymerase, nucleotidyltransferase, aids, cytoplasm, hydrolase, transferase, viral nucleoprotein
Biological sourceHuman immunodeficiency virus type 1 (HXB2 isolate) (HIV-1)
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Cellular locationMatrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585
Total number of polymer chains2
Total formula weight116439.91
Authors
Harris, S.F.,Villasenor, A.,Dunten, P. (deposition date: 2008-06-19, release date: 2008-08-19, Last modification date: 2011-07-13)
Primary citationDunn, J.P.,Dunten, P.,Elworthy, T.R.,Han, X.,Harris, S.F.,Heilek, G.,Hirschfeld, D.R.,Hogg, J.H.,Huber, W.,Kaiser, A.C.,Kertesz, D.J.,Kim, W.,Klumpp, K.,Li, Y.,Mirzadegan, T.,Roepel, M.G.,Saito, Y.D.,Silva, T.M.,Swallow, S.,Sweeney, Z.K.,Tracy, J.L.,Villasenor, A.,Vora, H.,Zhou, A.S.
Discovery and optimization of pyridazinone non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Bioorg.Med.Chem.Lett., 18:4352-4354, 2008
PubMed: 18632268
DOI: 110.1016/j.bmcl.2008.06.072
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.65 Å)
Structure validation
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PDB entries from 2021-06-16