3DHD

Crystal structure of human NAMPT complexed with nicotinamide mononucleotide and pyrophosphate

3DHD の概要

• エントリーDOI: 10.2210/pdb3dhd/pdb
• 関連するPDBエントリー: 3DGR 3DHF 3DKJ 3DKL
• 分子名称: Nicotinamide phosphoribosyltransferase, MAGNESIUM ION, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, ... (5 entities in total)
• 機能のキーワード: transferase, nmprtase, namprtase, visfatin, nmn, nicotinamide d-ribonucleotide, pyrophosphate, alternative splicing, cytoplasm, glycosyltransferase, phosphoprotein, polymorphism, pyridine nucleotide biosynthesis
• 由来する生物種: Homo sapiens
• 細胞内の位置: Nucleus : P43490
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 110729.81

構造登録者

Ho, M.,Burgos, E.S.,Almo, S.C.,Schramm, V.L. (登録日: 2008-06-17, 公開日: 2009-08-18, 最終更新日: 2023-08-30)

• 主引用文献: Burgos, E.S.,Ho, M.C.,Almo, S.C.,Schramm, V.L.; A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT.; Proc.Natl.Acad.Sci.USA, 106:13748-13753, 2009; PubMed: 19666527; DOI: 10.1073/pnas.0903898106

実験手法

X-RAY DIFFRACTION (2 Å)