3DDB
Crystal structure of the catalytic domain of Botulinum neurotoxin serotype a with a substrate analog peptide
Summary for 3DDB
Entry DOI | 10.2210/pdb3ddb/pdb |
Related | 3BWI 3C88 3C89 3C8A 3C8B 3DDA |
Descriptor | Botulinum neurotoxin A light chain, Synaptosomal-associated protein 25, ZINC ION, ... (5 entities in total) |
Functional Keywords | botulinum neurotoxin type a, botox, catalytic domain, endopeptidase, syntaxin, bio-warfare agent, hydrolase, metal-binding, metalloprotease, protease, secreted, transmembrane, zinc, enzyme-substrate complex, pharmaceutical |
Biological source | Clostridium botulinum More |
Cellular location | Botulinum neurotoxin A light chain: Secreted. Botulinum neurotoxin A heavy chain: Secreted: A5HZZ9 |
Total number of polymer chains | 2 |
Total formula weight | 50436.23 |
Authors | Kumaran, D.,Swaminathan, S. (deposition date: 2008-06-05, release date: 2008-09-16, Last modification date: 2023-08-30) |
Primary citation | Kumaran, D.,Rawat, R.,Ahmed, S.A.,Swaminathan, S. Substrate binding mode and its implication on drug design for botulinum neurotoxin A Plos Pathog., 4:e1000165-e1000165, 2008 Cited by PubMed: 18818739DOI: 10.1371/journal.ppat.1000165 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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