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3DC9

Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties

Summary for 3DC9
Entry DOI10.2210/pdb3dc9/pdb
Related3D8W 3D9Z 3DAZ 3DBU 3DC3 3DCC
DescriptorCarbonic anhydrase 2, ZINC ION (3 entities in total)
Functional Keywordscarbonic anhydrase ii complex, caix mimic inhibitors, acetylation, cytoplasm, disease mutation, lyase, metal-binding, polymorphism, zinc
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: P00918
Total number of polymer chains1
Total formula weight29384.49
Authors
Genis, C.,Sippel, K.H.,Case, N.,Govindasamy, L.,Agbandje-Mckenna, M.,Mckenna, R. (deposition date: 2008-06-03, release date: 2009-03-03, Last modification date: 2023-08-30)
Primary citationGenis, C.,Sippel, K.H.,Case, N.,Cao, W.,Avvaru, B.S.,Tartaglia, L.J.,Govindasamy, L.,Tu, C.,Agbandje-McKenna, M.,Silverman, D.N.,Rosser, C.J.,McKenna, R.
Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties
Biochemistry, 48:1322-1331, 2009
Cited by
PubMed: 19170619
DOI: 10.1021/bi802035f
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.6 Å)
Structure validation

217705

건을2024-03-27부터공개중

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