3D9Z
Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties
Summary for 3D9Z
Entry DOI | 10.2210/pdb3d9z/pdb |
Related | 3D8W 3DAZ 3DBU 3DC3 3DC9 3DCC 3DCS 3DCW 3DD0 |
Descriptor | Carbonic anhydrase 2, ZINC ION, 5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide (3 entities in total) |
Functional Keywords | carbonic anhydrase ii complex, caix mimic inhibitors, acetylation, cytoplasm, disease mutation, lyase, metal-binding, polymorphism, zinc |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P00918 |
Total number of polymer chains | 1 |
Total formula weight | 29630.21 |
Authors | Genis, C.,Sippel, K.H.,Case, N.,Govindasamy, L.,Agbandje-Mckenna, M.,Mckenna, R. (deposition date: 2008-05-28, release date: 2009-03-03, Last modification date: 2023-08-30) |
Primary citation | Genis, C.,Sippel, K.H.,Case, N.,Cao, W.,Avvaru, B.S.,Tartaglia, L.J.,Govindasamy, L.,Tu, C.,Agbandje-McKenna, M.,Silverman, D.N.,Rosser, C.J.,McKenna, R. Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties Biochemistry, 48:1322-1331, 2009 Cited by PubMed: 19170619DOI: 10.1021/bi802035f PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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