3DAT

Crystal structure of the ternary MTX NADPH complex of Bacillus anthracis dihydrofolate reductase

3DAT の概要

• エントリーDOI: 10.2210/pdb3dat/pdb
• 関連するPDBエントリー: 2QK8
• 分子名称: Dihydrofolate reductase, METHOTREXATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
• 機能のキーワード: dual-site inhibition, oxidoreductase, pseudo-rossmann fold, adenine nucleotide binding domain
• 由来する生物種: Bacillus anthracis str.
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 20348.71

構造登録者

Bennett, B.C.,Dealwis, C.G. (登録日: 2008-05-30, 公開日: 2009-04-14, 最終更新日: 2023-08-30)

• 主引用文献: Bennett, B.C.,Wan, Q.,Ahmad, M.F.,Langan, P.,Dealwis, C.G.; X-ray structure of the ternary MTX.NADPH complex of the anthrax dihydrofolate reductase: a pharmacophore for dual-site inhibitor design.; J.Struct.Biol., 166:162-171, 2009; PubMed: 19374017

実験手法

X-RAY DIFFRACTION (2.3 Å)