3D7V
Crystal structure of Mcl-1 in complex with an Mcl-1 selective BH3 ligand
Summary for 3D7V
Entry DOI | 10.2210/pdb3d7v/pdb |
Related | 1WSX 2NL9 2NLA |
Descriptor | Induced myeloid leukemia cell differentiation protein Mcl-1, Bcl-2-like protein 11, ZINC ION, ... (4 entities in total) |
Functional Keywords | helical bundle, amphipathic helix, alternative splicing, apoptosis, cytoplasm, developmental protein, differentiation, membrane, mitochondrion, nucleus, phosphoprotein, polymorphism, transmembrane, ubl conjugation |
Biological source | Mus musculus (mouse, human) More |
Cellular location | Membrane ; Single-pass membrane protein : Q07820 Endomembrane system ; Peripheral membrane protein . Isoform BimEL: Mitochondrion. Isoform BimL: Mitochondrion. Isoform BimS: Mitochondrion. Isoform Bim-alpha1: Mitochondrion: O43521 |
Total number of polymer chains | 2 |
Total formula weight | 21645.74 |
Authors | Lee, E.F.,Czabotar, P.E.,Colman, P.M.,Fairlie, W.D. (deposition date: 2008-05-22, release date: 2008-06-24, Last modification date: 2023-11-01) |
Primary citation | Lee, E.F.,Czabotar, P.E.,van Delft, M.F.,Michalak, E.M.,Boyle, M.J.,Willis, S.N.,Puthalakath, H.,Bouillet, P.,Colman, P.M.,Huang, D.C.S.,Fairlie, W.D. A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation. J.Cell Biol., 180:341-355, 2008 Cited by PubMed: 18209102DOI: 10.1083/jcb.200708096 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.03 Å) |
Structure validation
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