3D7V

Crystal structure of Mcl-1 in complex with an Mcl-1 selective BH3 ligand

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Induced myeloid leukemia cell differentiation protein Mcl-1	polymer	162	18227.6	1	UniProt (P97287) UniProt (Q07820) Pfam (PF00452) In PDB	Mus musculus (mouse human)	Bcl-2-related protein EAT/mcl1, mcl1/EAT
2	B	Bcl-2-like protein 11	polymer	26	3156.5	1	UniProt (O43521) Pfam (PF08945) In PDB	synthetic construct	Bcl2-interacting mediator of cell death
3	A	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
4		water	water		18.0	120	Chemie (HOH)

Sequence modifications

A: 171 - 208 (UniProt: P97287)

PDB	External Database	Details
Gly 166	-	expression tag
Pro 167	-	expression tag
Leu 168	-	expression tag
Gly 169	-	expression tag
Ser 170	-	expression tag

A: 209 - 327 (UniProt: Q07820)
B: 51 - 76 (UniProt: O43521)

PDB	External Database	Details
Ala 62	Leu 152	engineered mutation
Ala 69	Phe 159	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	21384.1
Non-Polymers*	Number of molecules	4
	Total formula weight	261.6
All*	Total formula weight	21645.7

*Water molecules are not included.