3D7B

The Ribonuclease A- 5'-Deoxy-5'-N-pyrrolidinouridine complex

3D7B の概要

• エントリーDOI: 10.2210/pdb3d7b/pdb
• 関連するPDBエントリー: 3D6O 3D6P 3D6Q
• 分子名称: Ribonuclease pancreatic, CITRATE ANION, 1-(5-deoxy-5-pyrrolidin-1-yl-alpha-L-arabinofuranosyl)pyrimidine-2,4(1H,3H)-dione, ... (4 entities in total)
• 機能のキーワード: hydrolase, ribonuclease a, ligand, endonuclease, glycation, glycoprotein, nuclease, secreted
• 由来する生物種: Bos taurus (bovine)
• 細胞内の位置: Secreted: P61823
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28092.16

構造登録者

Leonidas, D.D.,Zographos, S.E.,Oikonomakos, N.G. (登録日: 2008-05-21, 公開日: 2009-02-10, 最終更新日: 2023-08-30)

• 主引用文献: Samanta, A.,Leonidas, D.D.,Dasgupta, S.,Pathak, T.,Zographos, S.E.,Oikonomakos, N.G.; Morpholino, piperidino, and pyrrolidino derivatives of pyrimidine nucleosides as inhibitors of ribonuclease A: synthesis, biochemical, and crystallographic evaluation.; J.Med.Chem., 52:932-942, 2009; PubMed: 19173562; DOI: 10.1021/jm800724t

実験手法

X-RAY DIFFRACTION (1.6 Å)