3D6T

Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase

Summary for 3D6T

• Entry DOI: 10.2210/pdb3d6t/pdb
• Descriptor: Leucine-rich repeat serine/threonine-protein kinase 2, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... (4 entities in total)
• Functional Keywords: parkinson's disease, lrrk2, roc, roco, gtpase, kinase, atp-binding, disease mutation, gtp-binding, gtpase activation, leucine-rich repeat, membrane, nucleotide-binding, parkinson disease, serine/threonine-protein kinase, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Membrane; Peripheral membrane protein: Q5S007
• Total number of polymer chains: 1
• Total formula weight: 20270.46

Authors

Deng, J. (deposition date: 2008-05-20, release date: 2008-06-10, Last modification date: 2018-02-28)

• Primary citation: Deng, J.,Lewis, P.A.,Greggio, E.,Sluch, E.,Beilina, A.,Cookson, M.R.; Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase; Proc.Natl.Acad.Sci.Usa, 105:1499-1504, 2008; PubMed: 18230735; DOI: 10.1073/pnas.0709098105

Experimental method

X-RAY DIFFRACTION (2.43 Å)