3D6T

Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase

3D6T の概要

• エントリーDOI: 10.2210/pdb3d6t/pdb
• 分子名称: Leucine-rich repeat serine/threonine-protein kinase 2, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... (4 entities in total)
• 機能のキーワード: parkinson's disease, lrrk2, roc, roco, gtpase, kinase, atp-binding, disease mutation, gtp-binding, gtpase activation, leucine-rich repeat, membrane, nucleotide-binding, parkinson disease, serine/threonine-protein kinase, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Membrane; Peripheral membrane protein: Q5S007
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 20270.46

構造登録者

Deng, J. (登録日: 2008-05-20, 公開日: 2008-06-10, 最終更新日: 2018-02-28)

• 主引用文献: Deng, J.,Lewis, P.A.,Greggio, E.,Sluch, E.,Beilina, A.,Cookson, M.R.; Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase; Proc.Natl.Acad.Sci.Usa, 105:1499-1504, 2008; PubMed: 18230735; DOI: 10.1073/pnas.0709098105

実験手法

X-RAY DIFFRACTION (2.43 Å)