3D6O

The RNase A- 5'-Deoxy-5'-N-(ethyl isonipecotatyl)uridine complex

3D6O の概要

• エントリーDOI: 10.2210/pdb3d6o/pdb
• 関連するPDBエントリー: 3D6P 3D6Q 3D7B
• 分子名称: Ribonuclease pancreatic, 1-{5-deoxy-5-[4-(ethoxycarbonyl)piperidin-1-yl]-alpha-L-arabinofuranosyl}pyrimidine-2,4(1H,3H)-dione (3 entities in total)
• 機能のキーワード: hydrolase, ribonuclease, uridine complex, endonuclease, glycation, glycoprotein, nuclease, secreted
• 由来する生物種: Bos taurus (bovine)
• 細胞内の位置: Secreted: P61823
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 27800.05

構造登録者

Leonidas, D.D.,Zographos, S.E.,Oikonomakos, N.G. (登録日: 2008-05-20, 公開日: 2009-02-10, 最終更新日: 2023-08-30)

• 主引用文献: Samanta, A.,Leonidas, D.D.,Dasgupta, S.,Pathak, T.,Zographos, S.E.,Oikonomakos, N.G.; Morpholino, piperidino, and pyrrolidino derivatives of pyrimidine nucleosides as inhibitors of ribonuclease A: synthesis, biochemical, and crystallographic evaluation.; J.Med.Chem., 52:932-942, 2009; PubMed: 19173562; DOI: 10.1021/jm800724t

実験手法

X-RAY DIFFRACTION (1.58 Å)