3D5S

Crystal Structure of Efb-C (R131A) / C3d Complex

3D5S の概要

• エントリーDOI: 10.2210/pdb3d5s/pdb
• 関連するPDBエントリー: 2GOM 2GOX 2NOJ 3D5R
• 分子名称: Complement C3, Fibrinogen-binding protein (3 entities in total)
• 機能のキーワード: protein-protein complex, cell adhesion-toxin complex, site-directed mutation, age-related macular degeneration, cleavage on pair of basic residues, complement alternate pathway, complement pathway, disease mutation, glycoprotein, immune response, inflammatory response, innate immunity, phosphoprotein, polymorphism, secreted, thioester bond, cell adhesion/toxin
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P01024 A6QG59
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 81301.33

構造登録者

Geisbrecht, B.V. (登録日: 2008-05-16, 公開日: 2008-09-16, 最終更新日: 2023-08-30)

• 主引用文献: Haspel, N.,Ricklin, D.,Geisbrecht, B.V.,Kavraki, L.E.,Lambris, J.D.; Electrostatic contributions drive the interaction between Staphylococcus aureus protein Efb-C and its complement target C3d.; Protein Sci., 17:1894-1906, 2008; PubMed: 18687868; DOI: 10.1110/ps.036624.108

実験手法

X-RAY DIFFRACTION (2.3 Å)