3D5S

Crystal Structure of Efb-C (R131A) / C3d Complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, B)	Complement C3	polymer	297	33143.9	2	UniProt (P01024) Pfam (PF07678)	Homo sapiens (human)	C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1
2	B, D (C, D)	Fibrinogen-binding protein	polymer	65	7506.8	2	UniProt (A6QG59) Pfam (PF12199)	Staphylococcus aureus subsp. aureus str. Newman
3	E, F, G, H (A, C, B, D)	water	water		18.0	140	Chemie (HOH)

Sequence modifications

A, B: 7 - 298 (UniProt: P01024)

PDB	External Database	Details
Gly 2	-	expression tag
Ser 3	-	expression tag
Arg 4	-	expression tag
Ser 5	-	expression tag
Thr 6	-	expression tag
Ala 21	Cys 1010	engineered mutation

C, D: 11 - 75 (UniProt: A6QG59)

PDB	External Database	Details
Ala 41	Arg 131	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	81301.3
All*	Total formula weight	81301.3

*Water molecules are not included.