3D5R

Crystal Structure of Efb-C (N138A) / C3d Complex

Summary for 3D5R

Entry DOI	10.2210/pdb3d5r/pdb
Related	2GOM 2GOX 2NOJ 3D5S
Descriptor	Complement C3, Fibrinogen-binding protein (3 entities in total)
Functional Keywords	protein-protein complex, cell adhesion-toxin complex, site-directed mutation, age-related macular degeneration, cleavage on pair of basic residues, complement alternate pathway, complement pathway, disease mutation, glycoprotein, immune response, inflammatory response, innate immunity, phosphoprotein, polymorphism, secreted, thioester bond, cell adhesion/toxin
Biological source	Homo sapiens (human) More
Cellular location	Secreted: P01024 A6QG59
Total number of polymer chains	4
Total formula weight	81387.51
Authors	Geisbrecht, B.V. (deposition date: 2008-05-16, release date: 2008-09-09, Last modification date: 2023-08-30)
Primary citation	Haspel, N.,Ricklin, D.,Geisbrecht, B.V.,Kavraki, L.E.,Lambris, J.D. Electrostatic contributions drive the interaction between Staphylococcus aureus protein Efb-C and its complement target C3d. Protein Sci., 17:1894-1906, 2008 Cited by PubMed: 18687868 DOI: 10.1110/ps.036624.108 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation