3D4L

Human dipeptidyl peptidase IV/CD26 in complex with a novel inhibitor

Summary for 3D4L

Entry DOI	10.2210/pdb3d4l/pdb
Descriptor	Dipeptidyl peptidase 4 soluble form, 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywords	alpha/beta, beta-propeller, dimer, aminopeptidase, glycoprotein, hydrolase, membrane, protease, secreted, serine protease, signal-anchor, transmembrane
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	174827.90
Authors	Scapin, G. (deposition date: 2008-05-14, release date: 2008-07-01, Last modification date: 2023-08-30)
Primary citation	Liang, G.B.,Qian, X.,Biftu, T.,Singh, S.,Gao, Y.D.,Scapin, G.,Patel, S.,Leiting, B.,Patel, R.,Wu, J.,Zhang, X.,Thornberry, N.A.,Weber, A.E. Discovery of new binding elements in DPP-4 inhibition and their applications in novel DPP-4 inhibitor design. Bioorg.Med.Chem.Lett., 18:3706-3710, 2008 Cited by PubMed: 18524582 DOI: 10.1016/j.bmcl.2008.05.061 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation