3D48

Crystal structure of a prolactin receptor antagonist bound to the extracellular domain of the prolactin receptor

3D48 の概要

• エントリーDOI: 10.2210/pdb3d48/pdb
• 関連するPDBエントリー: 1BP3 1F6F 1N9D 1RW5 2Q98
• 分子名称: Prolactin, Prolactin receptor, CARBONATE ION, ... (4 entities in total)
• 機能のキーワード: cytokine-cytokine receptor complex, four-helix bundle, glycoprotein, hormone, lactation, secreted, alternative splicing, membrane, receptor, transmembrane, hormone-hormone receptor complex, hormone/hormone receptor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P01236; Membrane ; Single-pass type I membrane protein . Isoform 7: Secreted: P16471
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 46717.89

構造登録者

Svensson, L.A.,Breinholt, J. (登録日: 2008-05-14, 公開日: 2008-06-03, 最終更新日: 2023-11-01)

• 主引用文献: Svensson, L.A.,Bondensgaard, K.,Norskov-Lauritsen, L.,Christensen, L.,Becker, P.,Andersen, M.D.,Maltesen, M.J.,Rand, K.D.,Breinholt, J.; Crystal structure of a prolactin receptor antagonist bound to the extracellular domain of the prolactin receptor; J.Biol.Chem., 283:19085-19094, 2008; PubMed: 18467331; DOI: 10.1074/jbc.M801202200

実験手法

X-RAY DIFFRACTION (2.5 Å)