3D48
Crystal structure of a prolactin receptor antagonist bound to the extracellular domain of the prolactin receptor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (P) | Prolactin | polymer | 188 | 21948.0 | 1 | UniProt (P01236) Pfam (PF00103) | Homo sapiens (human) | PRL |
| 2 | B (R) | Prolactin receptor | polymer | 211 | 24529.8 | 1 | UniProt (P16471) Pfam (PF09067) | Homo sapiens (human) | PRL-R |
| 3 | C, D, E, F (P, R) | CARBONATE ION | non-polymer | 60.0 | 4 | Chemie (CO3) | |||
| 4 | G, H (P, R) | water | water | 18.0 | 103 | Chemie (HOH) |
Sequence modifications
P: 12 - 199 (UniProt: P01236)
R: 1 - 210 (UniProt: P16471)
| PDB | External Database | Details |
|---|---|---|
| Ser 12 | Gln 40 | engineered mutation |
| Arg 129 | Gly 157 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 46477.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 240.0 | |
| All* | Total formula weight | 46717.9 |
