3D48

Crystal structure of a prolactin receptor antagonist bound to the extracellular domain of the prolactin receptor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	P	Prolactin	polymer	188	21948.0	1	UniProt (P01236) Pfam (PF00103) In PDB	Homo sapiens (human)	PRL
2	R	Prolactin receptor	polymer	211	24529.8	1	UniProt (P16471) Pfam (PF09067) In PDB	Homo sapiens (human)	PRL-R
3	P, R	CARBONATE ION	non-polymer		60.0	4	Chemie (CO3)
4		water	water		18.0	103	Chemie (HOH)

Sequence modifications

P: 12 - 199 (UniProt: P01236)

PDB	External Database	Details
Ser 12	Gln 40	engineered mutation
Arg 129	Gly 157	engineered mutation

R: 1 - 210 (UniProt: P16471)

PDB	External Database	Details
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	46477.8
Non-Polymers*	Number of molecules	4
	Total formula weight	240.0
All*	Total formula weight	46717.9

*Water molecules are not included.