3D1V

Crystal structure of human PNP complexed with 2-mercapto(3H) quinazolinone

3D1V の概要

• エントリーDOI: 10.2210/pdb3d1v/pdb
• 関連するPDBエントリー: 1m73 1pf7
• 分子名称: Purine nucleoside phosphorylase, SULFATE ION, 2-mercapto(3H)quinazolinone, ... (4 entities in total)
• 機能のキーワード: purine nucleoside phosphorylase, drug design, synchrotron, empirical scoring function, 2-mercapto-4(3h) quinazolinone, acetylation, disease mutation, glycosyltransferase, polymorphism, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm, cytoskeleton (By similarity): P00491
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32651.28

構造登録者

De Azevedo Jr., W.F.,Basso, L.A.,Santos, D.S. (登録日: 2008-05-06, 公開日: 2009-07-14, 最終更新日: 2023-08-30)

• 主引用文献: Timmers, L.F.,Caceres, R.A.,Vivan, A.L.,Gava, L.M.,Dias, R.,Ducati, R.G.,Basso, L.A.,Santos, D.S.,de Azevedo, W.F.; Structural studies of human purine nucleoside phosphorylase: towards a new specific empirical scoring function; Arch.Biochem.Biophys., 479:28-38, 2008; PubMed: 18790691; DOI: 10.1016/j.abb.2008.08.015

実験手法

X-RAY DIFFRACTION (2.7 Å)