3D15
Crystal structure of mouse Aurora A (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with 1-(3-chloro-phenyl)-3-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)- ethyl]-thiazol-2-yl}-urea [SNS-314]
Summary for 3D15
Entry DOI | 10.2210/pdb3d15/pdb |
Related | 1mq4 3d14 |
Descriptor | serine/threonine kinase 6, 1-(3-chlorophenyl)-3-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}urea (3 entities in total) |
Functional Keywords | aurora a, small-molecule inhibitor, kinase, transferase |
Biological source | Mus musculus (Mouse) |
Total number of polymer chains | 1 |
Total formula weight | 31980.11 |
Authors | Elling, R.A.,Bui, M.,Allen, D.A.,Oslob, J.D.,Romanowski, M.J. (deposition date: 2008-05-04, release date: 2009-05-12, Last modification date: 2023-08-30) |
Primary citation | Oslob, J.D.,Romanowski, M.J.,Allen, D.A.,Baskaran, S.,Bui, M.,Elling, R.A.,Flanagan, W.M.,Fung, A.D.,Hanan, E.J.,Harris, S.,Heumann, S.A.,Hoch, U.,Jacobs, J.W.,Lam, J.,Lawrence, C.E.,McDowell, R.S.,Nannini, M.A.,Shen, W.,Silverman, J.A.,Sopko, M.M.,Tangonan, B.T.,Teague, J.,Yoburn, J.C.,Yu, C.H.,Zhong, M.,Zimmerman, K.M.,O'Brien, T.,Lew, W. Discovery of a potent and selective aurora kinase inhibitor. Bioorg.Med.Chem.Lett., 18:4880-4884, 2008 Cited by PubMed: 18678489DOI: 10.1016/j.bmcl.2008.07.073 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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