3D0E
Crystal structure of human Akt2 in complex with GSK690693
Summary for 3D0E
Entry DOI | 10.2210/pdb3d0e/pdb |
Descriptor | RAC-beta serine/threonine-protein kinase, 4-{2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-piperidin-3-ylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl}-2-methylbut-3-yn-2-ol (3 entities in total) |
Functional Keywords | human, akt2, inhibitor, atp-binding, kinase, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, transferase inhibitor |
Biological source | Homo sapiens |
Cellular location | Cytoplasm: P31751 |
Total number of polymer chains | 2 |
Total formula weight | 78995.99 |
Authors | Concha, N.O.,Smallwood, A. (deposition date: 2008-05-01, release date: 2008-10-21, Last modification date: 2017-10-25) |
Primary citation | Heerding, D.A.,Rhodes, N.,Leber, J.D.,Clark, T.J.,Keenan, R.M.,Lafrance, L.V.,Li, M.,Safonov, I.G.,Takata, D.T.,Venslavsky, J.W.,Yamashita, D.S.,Choudhry, A.E.,Copeland, R.A.,Lai, Z.,Schaber, M.D.,Tummino, P.J.,Strum, S.L.,Wood, E.R.,Duckett, D.R.,Eberwein, D.,Knick, V.B.,Lansing, T.J.,McConnell, R.T.,Zhang, S.,Minthorn, E.A.,Concha, N.O.,Warren, G.L.,Kumar, R. Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase. J.Med.Chem., 51:5663-5679, 2008 Cited by PubMed: 18800763DOI: 10.1021/jm8004527 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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