3CXC

The structure of an enhanced oxazolidinone inhibitor bound to the 50S ribosomal subunit of H. marismortui

3CXC の概要

• エントリーDOI: 10.2210/pdb3cxc/pdb
• 分子名称: 23S RIBOSOMAL RNA, RIBOSOMAL PROTEIN L10, RIBOSOMAL PROTEIN L10E, ... (38 entities in total)
• 機能のキーワード: 50s ribosomal subunit, oxazolidinone, ribosome
• 由来する生物種: Haloarcula marismortui; 詳細
• タンパク質・核酸の鎖数: 31
• 化学式量合計: 1459563.32

構造登録者

Ippolito, J.A.,Wang, D.,Kanyo, Z.F.,Duffy, E.M. (登録日: 2008-04-24, 公開日: 2009-04-28, 最終更新日: 2023-08-30)

主引用文献

Zhou, J.,Bhattacharjee, A.,Chen, S.,Chen, Y.,Duffy, E.,Farmer, J.,Goldberg, J.,Hanselmann, R.,Ippolito, J.A.,Lou, R.,Orbin, A.,Oyelere, A.,Salvino, J.,Springer, D.,Tran, J.,Wang, D.,Wu, Y.,Johnson, G.
Design at the atomic level: design of biaryloxazolidinones as potent orally active antibiotics.
Bioorg.Med.Chem.Lett., 18:6175-6178, 2008

PubMed Abstract: We have developed a first generation of hybrid sparsomycin-linezolid compounds into a new family of orally bioavailable biaryloxazolidinones that have activity against both linezolid-susceptible and -resistant gram-positive bacteria as well as the fastidious gram-negative bacteria Haemophilus influenzae and Moraxella catarrahalis. The convergent synthesis of these new compounds is detailed.

PubMed: 18947996
DOI: 10.1016/j.bmcl.2008.10.011

実験手法

X-RAY DIFFRACTION (3 Å)