3CWJ
Crystal structure of hcv ns5b polymerase with a novel pyridazinone inhibitor
Summary for 3CWJ
Entry DOI | 10.2210/pdb3cwj/pdb |
Related | 3BR9 3BSA 3BSC 3CDE 3CO9 3CVK |
Descriptor | RNA-DIRECTED RNA POLYMERASE, N-{3-[5-hydroxy-2-(3-methylbutyl)-3-oxo-6-thiophen-2-yl-2,3-dihydropyridazin-4-yl]-1,1-dioxido-2H-1,4-benzothiazin-7-yl}methanesulfonamide (3 entities in total) |
Functional Keywords | protein-ligand complex, rna replication, rna-binding, rna-directed rna polymerase, hepatitis, transferase, viral protein |
Biological source | Hepatitis C virus |
Total number of polymer chains | 2 |
Total formula weight | 129764.76 |
Authors | Han, Q.,Showalter, R.E.,Zhao, Q.,Kissinger, C.R. (deposition date: 2008-04-21, release date: 2009-04-21, Last modification date: 2024-04-03) |
Primary citation | Ellis, D.A.,Blazel, J.K.,Webber, S.E.,Tran, C.V.,Dragovich, P.S.,Sun, Z.,Ruebsam, F.,McGuire, H.M.,Xiang, A.X.,Zhao, J.,Li, L.S.,Zhou, Y.,Han, Q.,Kissinger, C.R.,Showalter, R.E.,Lardy, M.,Shah, A.M.,Tsan, M.,Patel, R.,LeBrun, L.A.,Kamran, R.,Bartkowski, D.M.,Nolan, T.G.,Norris, D.A.,Sergeeva, M.V.,Kirkovsky, L. 4-(1,1-Dioxo-1,4-dihydro-1lambda6-benzo[1,4]thiazin-3-yl)-5-hydroxy-2H-pyridazin-3-ones as potent inhibitors of HCV NS5B polymerase Bioorg.Med.Chem.Lett., 18:4628-4632, 2008 Cited by PubMed: 18662878DOI: 10.1016/j.bmcl.2008.07.014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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