3CWJ

Crystal structure of hcv ns5b polymerase with a novel pyridazinone inhibitor

3CWJ の概要

• エントリーDOI: 10.2210/pdb3cwj/pdb
• 関連するPDBエントリー: 3BR9 3BSA 3BSC 3CDE 3CO9 3CVK
• 分子名称: RNA-DIRECTED RNA POLYMERASE, N-{3-[5-hydroxy-2-(3-methylbutyl)-3-oxo-6-thiophen-2-yl-2,3-dihydropyridazin-4-yl]-1,1-dioxido-2H-1,4-benzothiazin-7-yl}methanesulfonamide (3 entities in total)
• 機能のキーワード: protein-ligand complex, rna replication, rna-binding, rna-directed rna polymerase, hepatitis, transferase, viral protein
• 由来する生物種: Hepatitis C virus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 129764.76

構造登録者

Han, Q.,Showalter, R.E.,Zhao, Q.,Kissinger, C.R. (登録日: 2008-04-21, 公開日: 2009-04-21, 最終更新日: 2024-04-03)

• 主引用文献: Ellis, D.A.,Blazel, J.K.,Webber, S.E.,Tran, C.V.,Dragovich, P.S.,Sun, Z.,Ruebsam, F.,McGuire, H.M.,Xiang, A.X.,Zhao, J.,Li, L.S.,Zhou, Y.,Han, Q.,Kissinger, C.R.,Showalter, R.E.,Lardy, M.,Shah, A.M.,Tsan, M.,Patel, R.,LeBrun, L.A.,Kamran, R.,Bartkowski, D.M.,Nolan, T.G.,Norris, D.A.,Sergeeva, M.V.,Kirkovsky, L.; 4-(1,1-Dioxo-1,4-dihydro-1lambda6-benzo[1,4]thiazin-3-yl)-5-hydroxy-2H-pyridazin-3-ones as potent inhibitors of HCV NS5B polymerase; Bioorg.Med.Chem.Lett., 18:4628-4632, 2008; PubMed: 18662878; DOI: 10.1016/j.bmcl.2008.07.014

実験手法

X-RAY DIFFRACTION (2.4 Å)