3CWD
Molecular recognition of nitro-fatty acids by PPAR gamma
Summary for 3CWD
| Entry DOI | 10.2210/pdb3cwd/pdb |
| Descriptor | Peroxisome proliferator-activated receptor gamma, SRC1-2 PEPTIDE, (9E,12Z)-10-nitrooctadeca-9,12-dienoic acid, ... (5 entities in total) |
| Functional Keywords | ppar gamma, nuclear receptor, src1-2 motif, activator, alternative splicing, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphoprotein, polymorphism, transcription, transcription regulation, zinc, zinc-finger |
| Biological source | Homo sapiens (Human) |
| Cellular location | Nucleus: P37231 Nucleus (By similarity): Q15788 |
| Total number of polymer chains | 4 |
| Total formula weight | 66847.96 |
| Authors | Martynowski, D.,Li, Y. (deposition date: 2008-04-21, release date: 2008-07-08, Last modification date: 2024-02-21) |
| Primary citation | Li, Y.,Zhang, J.,Schopfer, F.J.,Martynowski, D.,Garcia-Barrio, M.T.,Kovach, A.,Suino-Powell, K.,Baker, P.R.,Freeman, B.A.,Chen, Y.E.,Xu, H.E. Molecular recognition of nitrated fatty acids by PPAR gamma. Nat.Struct.Mol.Biol., 15:865-867, 2008 Cited by PubMed Abstract: Peroxisome proliferator activated receptor-gamma (PPAR gamma) regulates metabolic homeostasis and adipocyte differentiation, and it is activated by oxidized and nitrated fatty acids. Here we report the crystal structure of the PPAR gamma ligand binding domain bound to nitrated linoleic acid, a potent endogenous ligand of PPAR gamma. Structural and functional studies of receptor-ligand interactions reveal the molecular basis of PPAR gamma discrimination of various naturally occurring fatty acid derivatives. PubMed: 18604218DOI: 10.1038/nsmb.1447 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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