3CWD

Molecular recognition of nitro-fatty acids by PPAR gamma

3CWD の概要

• エントリーDOI: 10.2210/pdb3cwd/pdb
• 分子名称: Peroxisome proliferator-activated receptor gamma, SRC1-2 PEPTIDE, (9E,12Z)-10-nitrooctadeca-9,12-dienoic acid, ... (5 entities in total)
• 機能のキーワード: ppar gamma, nuclear receptor, src1-2 motif, activator, alternative splicing, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphoprotein, polymorphism, transcription, transcription regulation, zinc, zinc-finger
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: P37231; Nucleus (By similarity): Q15788
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 66847.96

構造登録者

Martynowski, D.,Li, Y. (登録日: 2008-04-21, 公開日: 2008-07-08, 最終更新日: 2024-02-21)

主引用文献

Li, Y.,Zhang, J.,Schopfer, F.J.,Martynowski, D.,Garcia-Barrio, M.T.,Kovach, A.,Suino-Powell, K.,Baker, P.R.,Freeman, B.A.,Chen, Y.E.,Xu, H.E.
Molecular recognition of nitrated fatty acids by PPAR gamma.
Nat.Struct.Mol.Biol., 15:865-867, 2008

PubMed Abstract: Peroxisome proliferator activated receptor-gamma (PPAR gamma) regulates metabolic homeostasis and adipocyte differentiation, and it is activated by oxidized and nitrated fatty acids. Here we report the crystal structure of the PPAR gamma ligand binding domain bound to nitrated linoleic acid, a potent endogenous ligand of PPAR gamma. Structural and functional studies of receptor-ligand interactions reveal the molecular basis of PPAR gamma discrimination of various naturally occurring fatty acid derivatives.

PubMed: 18604218
DOI: 10.1038/nsmb.1447

実験手法

X-RAY DIFFRACTION (2.4 Å)