3CWB

Chicken Cytochrome BC1 Complex inhibited by an iodinated analogue of the polyketide Crocacin-D

Summary for 3CWB

• Entry DOI: 10.2210/pdb3cwb/pdb
• Descriptor: MITOCHONDRIAL UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX CORE PROTEIN I, MITOCHONDRIAL UBIQUINOL-CYTOCHROME C REDUCTASE 7.2 KDA PROTEIN, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, ... (21 entities in total)
• Functional Keywords: crocacin d, inhibitor design, structure-activity relationship, polyketide, fungicide, cytochrome bc1, membrane protein, heme protein, rieske iron sulfur protein, cytochrome b, cytochrome c1, complex iii, mitochondrial processing protea ubiquinone, oxidoreductase, redox enzyme, respiratory chain, electron transport, heme, inner membrane, iron, membrane, metal-binding, mitochondrion, transmembrane, transport
• Biological source: Gallus gallus (chicken); More
• Total number of polymer chains: 20
• Total formula weight: 481896.65

Authors

Huang, L.,Cromartie, T.,Viner, R.,Crowley, P.J.,Berry, E.A. (deposition date: 2008-04-21, release date: 2008-08-12, Last modification date: 2023-08-30)

• Primary citation: Crowley, P.J.,Berry, E.A.,Cromartie, T.,Daldal, F.,Godfrey, C.R.,Lee, D.W.,Phillips, J.E.,Taylor, A.,Viner, R.; The role of molecular modeling in the design of analogues of the fungicidal natural products crocacins A and D.; Bioorg.Med.Chem., 16:10345-10355, 2008; PubMed: 18996700; DOI: 10.1016/j.bmc.2008.10.030

Experimental method

X-RAY DIFFRACTION (3.51 Å)