3CVA

Human Bcl-xL containing a Trp to Ala mutation at position 137

Summary for 3CVA

• Entry DOI: 10.2210/pdb3cva/pdb
• Descriptor: Apoptosis regulator Bcl-X (2 entities in total)
• Functional Keywords: apoptosis, alternative splicing, membrane, mitochondrion, nucleus, transmembrane
• Biological source: Homo sapiens (Human)
• Cellular location: Isoform Bcl-X(L): Mitochondrion inner membrane : Q07817
• Total number of polymer chains: 1
• Total formula weight: 24604.97

Authors

Feng, Y.,Zhang, L.,Hu, T.,Shen, X.,Chen, K.,Jiang, H.,Liu, D. (deposition date: 2008-04-18, release date: 2009-03-24, Last modification date: 2023-11-01)

• Primary citation: Feng, Y.,Zhang, L.,Hu, T.,Shen, X.,Ding, J.,Chen, K.,Jiang, H.,Liu, D.; A conserved hydrophobic core at Bcl-x(L) mediates its structural stability and binding affinity with BH3-domain peptide of pro-apoptotic protein; Arch.Biochem.Biophys., 484:46-54, 2009; PubMed: 19161970; DOI: 10.1016/j.abb.2009.01.003

Experimental method

X-RAY DIFFRACTION (2.7 Å)