3CTH

Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-met in complex with a aminopyridine based inhibitor

3CTH の概要

• エントリーDOI: 10.2210/pdb3cth/pdb
• 関連するPDBエントリー: 3C1X 3CTJ 3CTK
• 分子名称: Hepatocyte growth factor receptor, N-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}carbamoyl)-2-(4-fluorophenyl)acetamide (3 entities in total)
• 機能のキーワード: receptor tyrosine kinase, signal transduction, grb2, shc, atp-binding, glycoprotein, membrane, nucleotide-binding, phosphoprotein, proto-oncogene, transferase, transmembrane, tyrosine-protein kinase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P08581
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35833.39

構造登録者

Sack, J. (登録日: 2008-04-14, 公開日: 2008-06-10, 最終更新日: 2024-02-21)

主引用文献

Cai, Z.-W.,Wei, D.,Schroeder, G.M.,Cornelius, L.A.,Kim, K.,Chen, X.-T.,Schmidt, R.J.,Williams, D.K.,Tokarski, J.S.,An, Y.,Sack, J.S.,Manne, V.,Kamath, A.,Zhang, Y.,Marathe, P.,Hunt, J.T.,Lombardo, L.J.,Fargnoli, J.,Borzilleri, R.M.
Discovery of orally active pyrrolopyridine- and aminopyridine-based Met kinase inhibitors
Bioorg.Med.Chem.Lett., 18:3224-3229, 2008

PubMed Abstract: A series of acylurea analogs derived from pyrrolopyridine and aminopyridine scaffolds were identified as potent inhibitors of Met kinase activity. The SAR at various positions of the two kinase scaffolds was investigated. These studies led to the discovery of compounds 3b and 20b, which demonstrated favorable pharmacokinetic properties in mice and significant antitumor activity in a human gastric carcinoma xenograft model.

PubMed: 18479916
DOI: 10.1016/j.bmcl.2008.04.047

実験手法

X-RAY DIFFRACTION (2.3 Å)