3CSO

HCV Polymerase in complex with a 1,5 Benzodiazepine inhibitor

Summary for 3CSO

• Entry DOI: 10.2210/pdb3cso/pdb
• Related: 1nb4
• Descriptor: RNA-directed RNA polymerase, (11S)-10-acetyl-11-[4-(benzyloxy)-3-chlorophenyl]-3,3-dimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one (3 entities in total)
• Functional Keywords: 1, 5-benzodiazepines, hepatitis c virus, ns5b, polymerase, transferase
• Biological source: Hepatitis C virus isolate
• Cellular location: Core protein p21: Host endoplasmic reticulum membrane ; Single-pass membrane protein . Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane ; Peripheral membrane protein . RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : O92972
• Total number of polymer chains: 2
• Total formula weight: 130636.56

Authors

Nyanguile, O. (deposition date: 2008-04-10, release date: 2009-04-14, Last modification date: 2024-02-21)

• Primary citation: Nyanguile, O.,Pauwels, F.,Van den Broeck, W.,Boutton, C.W.,Quirynen, L.,Ivens, T.,van der Helm, L.,Vandercruyssen, G.,Mostmans, W.,Delouvroy, F.,Dehertogh, P.,Cummings, M.D.,Bonfanti, J.F.,Simmen, K.A.,Raboisson, P.; 1,5-benzodiazepines, a novel class of hepatitis C virus polymerase nonnucleoside inhibitors.; Antimicrob.Agents Chemother., 52:4420-4431, 2008; PubMed: 18852280; DOI: 10.1128/AAC.00669-08

Experimental method

X-RAY DIFFRACTION (2.71 Å)