3CS9

Human ABL kinase in complex with nilotinib

3CS9 の概要

• エントリーDOI: 10.2210/pdb3cs9/pdb
• 関連するPDBエントリー: 2HYY
• 分子名称: Proto-oncogene tyrosine-protein kinase ABL1, Nilotinib (3 entities in total)
• 機能のキーワード: nilotinib, amn107, kinase, abl, alternative splicing, atp-binding, cell adhesion, chromosomal rearrangement, cytoplasm, cytoskeleton, lipoprotein, magnesium, manganese, metal-binding, myristate, nucleotide-binding, nucleus, phosphoprotein, polymorphism, proto-oncogene, sh2 domain, sh3 domain, transferase, tyrosine-protein kinase, abl kinase wt in complex with nvp-amn107
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm, cytoskeleton. Isoform IB: Nucleus membrane; Lipid-anchor: P00519
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 130320.80

構造登録者

Cowan-Jacob, S.W.,Fendrich, G.,Manley, P.,Liebetanz, J.,Fabbro, D. (登録日: 2008-04-09, 公開日: 2008-04-22, 最終更新日: 2024-04-03)

• 主引用文献: Weisberg, E.,Manley, P.W.,Breitenstein, W.,Brueggen, J.,Cowan-Jacob, S.W.,Ray, A.,Huntly, B.,Fabbro, D.,Fendrich, G.,Hall-Meyers, E.,Kung, A.L.,Mestan, J.,Daley, G.Q.,Callahan, L.,Catley, L.,Cavazza, C.,Azam, M.,Neuberg, D.,Wright, R.D.,Gilliland, D.G.,Griffin, J.D.; Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl; Cancer Cell, 7:129-141, 2005; PubMed: 15710326; DOI: 10.1016/j.ccr.2005.01.007

実験手法

X-RAY DIFFRACTION (2.21 Å)