3CS9
Human ABL kinase in complex with nilotinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Proto-oncogene tyrosine-protein kinase ABL1 | polymer | 277 | 32050.7 | 4 | UniProt (P00519) Pfam (PF07714) | Homo sapiens (human) | p150, c-ABL, Abelson murine leukemia viral oncogene homolog 1 |
| 2 | E, F, G, H (A, B, C, D) | Nilotinib | non-polymer | 529.5 | 4 | Chemie (NIL) | |||
| 3 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 266 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 229 - 500 (UniProt: P00519)
| PDB | External Database | Details |
|---|---|---|
| Gly 224 | - | expression tag |
| Ala 225 | - | expression tag |
| Met 226 | - | expression tag |
| Asp 227 | - | expression tag |
| Pro 228 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 128202.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2118.1 | |
| All* | Total formula weight | 130320.8 |
