3CQW

Crystal Structure of Akt-1 complexed with substrate peptide and inhibitor

3CQW の概要

• エントリーDOI: 10.2210/pdb3cqw/pdb
• 関連するPDBエントリー: 3CQU
• 分子名称: RAC-alpha serine/threonine-protein kinase, Glycogen synthase kinase-3 beta, MANGANESE (II) ION, ... (5 entities in total)
• 機能のキーワード: kinase, apoptosis, atp-binding, carbohydrate metabolism, cytoplasm, glucose metabolism, glycogen biosynthesis, glycogen metabolism, membrane, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, sugar transport, transferase, translation regulation, transport, alternative splicing, wnt signaling pathway
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm: P31749 P49841
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 41060.96

構造登録者

Pandit, J. (登録日: 2008-04-03, 公開日: 2008-05-27, 最終更新日: 2021-10-20)

• 主引用文献: Lippa, B.,Pan, G.,Corbett, M.,Li, C.,Kauffman, G.S.,Pandit, J.,Robinson, S.,Wei, L.,Kozina, E.,Marr, E.S.,Borzillo, G.,Knauth, E.,Barbacci-Tobin, E.G.,Vincent, P.,Troutman, M.,Baker, D.,Rajamohan, F.,Kakar, S.,Clark, T.,Morris, J.; Synthesis and structure based optimization of novel Akt inhibitors; Bioorg.Med.Chem.Lett., 18:3359-3363, 2008; PubMed: 18456494; DOI: 10.1016/j.bmcl.2008.04.034

実験手法

X-RAY DIFFRACTION (2 Å)