3COW

Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.8 Ang resolution- in complex with sulphonamide inhibitor 2

Summary for 3COW

• Entry DOI: 10.2210/pdb3cow/pdb
• Related: 1MOP 1N2H 3COV 3COY 3COZ
• Descriptor: Pantothenate synthetase, 5'-O-{[(2R)-2-hydroxy-3,3-dimethylbutanoyl]sulfamoyl}adenosine, GLYCEROL, ... (5 entities in total)
• Functional Keywords: mycobacterium tuberculosis, pantothenate biosynthesis, enzymes, ligase, inhibitors, drug design, atp-binding, magnesium, metal-binding, nucleotide-binding
• Biological source: Mycobacterium tuberculosis
• Cellular location: Cytoplasm (Potential): P0A5R0
• Total number of polymer chains: 2
• Total formula weight: 64339.60

Authors

Ciulli, A.,Chirgadze, D.Y.,Blundell, T.L.,Abell, C. (deposition date: 2008-03-29, release date: 2008-10-07, Last modification date: 2023-08-30)

• Primary citation: Ciulli, A.,Scott, D.E.,Ando, M.,Reyes, F.,Saldanha, S.A.,Tuck, K.L.,Chirgadze, D.Y.,Blundell, T.L.,Abell, C.; Inhibition of Mycobacterium tuberculosis pantothenate synthetase by analogues of the reaction intermediate.; Chembiochem, 9:2606-2611, 2008; PubMed: 18821554; DOI: 10.1002/cbic.200800437

Experimental method

X-RAY DIFFRACTION (1.8 Å)