3COJ
Crystal Structure of the BRCT Domains of Human BRCA1 in Complex with a Phosphorylated Peptide from Human Acetyl-CoA Carboxylase 1
3COJ の概要
エントリーDOI | 10.2210/pdb3coj/pdb |
関連するPDBエントリー | 1T15 1T29 1T2V 1Y98 2AZM |
分子名称 | Breast cancer type 1 susceptibility protein, Acetyl-CoA carboxylase 1 (2 entities in total) |
機能のキーワード | breast cancer, ovarian cancer, fatty acid biosynthesis, lipid synthesis, obesity, protein-peptide complex, protein protein interaction, anti-oncogene, cell cycle, disease mutation, dna damage, dna repair, dna-binding, metal-binding, nucleus, phosphoprotein, zinc-finger, alternative promoter usage, atp-binding, biotin, ligase, manganese, multifunctional enzyme, nucleotide-binding, antitumor protein-ligase complex, antitumor protein/ligase |
由来する生物種 | Homo sapiens (Human) 詳細 |
細胞内の位置 | Nucleus . Isoform 3: Cytoplasm. Isoform 5: Cytoplasm : P38398 Cytoplasm: Q13085 |
タンパク質・核酸の鎖数 | 16 |
化学式量合計 | 225945.22 |
構造登録者 | |
主引用文献 | Shen, Y.,Tong, L. Structural evidence for direct interactions between the BRCT domains of human BRCA1 and a phospho-peptide from human ACC1 Biochemistry, 47:5767-5773, 2008 Cited by PubMed: 18452305DOI: 10.1021/bi800314m 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (3.21 Å) |
構造検証レポート
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