3COG

Crystal structure of human cystathionase (Cystathionine gamma lyase) in complex with DL-propargylglycine

3COG の概要

• エントリーDOI: 10.2210/pdb3cog/pdb
• 関連するPDBエントリー: 2NMP
• 分子名称: Cystathionine gamma-lyase, NITRATE ION, PYRIDOXAL-5'-PHOSPHATE, ... (7 entities in total)
• 機能のキーワード: cth, plp, propargylglycine, sgc, inhibitor, structural genomics, sgc stockholm, structural genomics consortium, amino-acid biosynthesis, cysteine biosynthesis, disease mutation, lyase, phosphoprotein, pyridoxal phosphate
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: P32929
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 179182.11

構造登録者

Collins, R.,Karlberg, T.,Lehtio, L.,Arrowsmith, C.H.,Berglund, H.,Dahlgren, L.G.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, I.,Kallas, A.,Kotenyova, T.,Moche, M.,Nilsson, M.E.,Nordlund, P.,Nyman, T.,Olesen, K.,Persson, C.,Schuler, H.,Svensson, L.,Thorsell, A.G.,Tresaugues, L.,Van den Berg, S.,Sagermark, J.,Busam, R.D.,Welin, M.,Weigelt, J.,Wikstrom, M.,Structural Genomics Consortium (SGC) (登録日: 2008-03-28, 公開日: 2008-05-27, 最終更新日: 2023-08-30)

• 主引用文献: Sun, Q.,Collins, R.,Huang, S.,Holmberg-Schiavone, L.,Anand, G.S.,Tan, C.H.,van-den-Berg, S.,Deng, L.W.,Moore, P.K.,Karlberg, T.,Sivaraman, J.; Structural basis for the inhibition mechanism of human cystathionine gamma-lyase, an enzyme responsible for the production of H(2)S.; J.Biol.Chem., 284:3076-3085, 2009; PubMed: 19019829; DOI: 10.1074/jbc.M805459200

実験手法

X-RAY DIFFRACTION (2 Å)