3CLY

Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domains Trapped in Trans-Phosphorylation Reaction

Summary for 3CLY

Entry DOI	10.2210/pdb3cly/pdb
Related	2PSQ 2PVF
Descriptor	Fibroblast growth factor receptor 2, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (4 entities in total)
Functional Keywords	kinase domain, trans-phosphorylation, atp-binding, disease mutation, ectodermal dysplasia, glycoprotein, heparin-binding, immunoglobulin domain, lacrimo-auriculo-dento-digital syndrome, membrane, nucleotide-binding, phosphoprotein, receptor, secreted, transferase, transmembrane, tyrosine-protein kinase
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane; Single-pass type I membrane protein. Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cell membrane; Single-pass type I membrane protein. Isoform 14: Secreted. Isoform 19: Secreted: P21802
Total number of polymer chains	1
Total formula weight	39011.65
Authors	Chen, H.,Mohammadi, M. (deposition date: 2008-03-20, release date: 2009-02-03, Last modification date: 2023-11-15)
Primary citation	Chen, H.,Xu, C.F.,Ma, J.,Eliseenkova, A.V.,Li, W.,Pollock, P.M.,Pitteloud, N.,Miller, W.T.,Neubert, T.A.,Mohammadi, M. A crystallographic snapshot of tyrosine trans-phosphorylation in action Proc.Natl.Acad.Sci.USA, 105:19660-19665, 2008 Cited by PubMed: 19060208 DOI: 10.1073/pnas.0807752105 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation