3CLY

Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domains Trapped in Trans-Phosphorylation Reaction

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Fibroblast growth factor receptor 2	polymer	334	38457.8	1	UniProt (P21802) Pfam (PF07714) In PDB	Homo sapiens (Human)	FGFR-2, Keratinocyte growth factor receptor 2, CD332 antigen
2	A	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
3	A	PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER	non-polymer		505.2	1	Chemie (ACP)
4		water	water		18.0	107	Chemie (HOH)

Sequence modifications

A: 1458 - 1778 (UniProt: P21802)

PDB	External Database	Details
Met 1445	-	expression tag
Gly 1446	-	expression tag
Ser 1447	-	expression tag
Ser 1448	-	expression tag
His 1449	-	expression tag
His 1450	-	expression tag
His 1451	-	expression tag
His 1452	-	expression tag
His 1453	-	expression tag
His 1454	-	expression tag
Ser 1455	-	expression tag
Gln 1456	-	expression tag
Asp 1457	-	expression tag
Ala 1491	Cys 491	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	38457.8
Non-Polymers*	Number of molecules	3
	Total formula weight	553.8
All*	Total formula weight	39011.7

*Water molecules are not included.