3CLY
Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domains Trapped in Trans-Phosphorylation Reaction
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Fibroblast growth factor receptor 2 | polymer | 334 | 38457.8 | 1 | UniProt (P21802) Pfam (PF07714) | Homo sapiens (Human) | FGFR-2, Keratinocyte growth factor receptor 2, CD332 antigen |
| 2 | B, C (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 3 | D (A) | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | non-polymer | 505.2 | 1 | Chemie (ACP) | |||
| 4 | E (A) | water | water | 18.0 | 107 | Chemie (HOH) |
Sequence modifications
A: 1458 - 1778 (UniProt: P21802)
| PDB | External Database | Details |
|---|---|---|
| Met 1445 | - | expression tag |
| Gly 1446 | - | expression tag |
| Ser 1447 | - | expression tag |
| Ser 1448 | - | expression tag |
| His 1449 | - | expression tag |
| His 1450 | - | expression tag |
| His 1451 | - | expression tag |
| His 1452 | - | expression tag |
| His 1453 | - | expression tag |
| His 1454 | - | expression tag |
| Ser 1455 | - | expression tag |
| Gln 1456 | - | expression tag |
| Asp 1457 | - | expression tag |
| Ala 1491 | Cys 491 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 38457.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 553.8 | |
| All* | Total formula weight | 39011.7 |
