3CLY

Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domains Trapped in Trans-Phosphorylation Reaction

3CLY の概要

• エントリーDOI: 10.2210/pdb3cly/pdb
• 関連するPDBエントリー: 2PSQ 2PVF
• 分子名称: Fibroblast growth factor receptor 2, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (4 entities in total)
• 機能のキーワード: kinase domain, trans-phosphorylation, atp-binding, disease mutation, ectodermal dysplasia, glycoprotein, heparin-binding, immunoglobulin domain, lacrimo-auriculo-dento-digital syndrome, membrane, nucleotide-binding, phosphoprotein, receptor, secreted, transferase, transmembrane, tyrosine-protein kinase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein. Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cell membrane; Single-pass type I membrane protein. Isoform 14: Secreted. Isoform 19: Secreted: P21802
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 39011.65

構造登録者

Chen, H.,Mohammadi, M. (登録日: 2008-03-20, 公開日: 2009-02-03, 最終更新日: 2023-11-15)

• 主引用文献: Chen, H.,Xu, C.F.,Ma, J.,Eliseenkova, A.V.,Li, W.,Pollock, P.M.,Pitteloud, N.,Miller, W.T.,Neubert, T.A.,Mohammadi, M.; A crystallographic snapshot of tyrosine trans-phosphorylation in action; Proc.Natl.Acad.Sci.USA, 105:19660-19665, 2008; PubMed: 19060208; DOI: 10.1073/pnas.0807752105

実験手法

X-RAY DIFFRACTION (2 Å)