3CLX

Crystal structure of XIAP BIR3 domain in complex with a Smac-mimetic compound, Smac005

3CLX の概要

• エントリーDOI: 10.2210/pdb3clx/pdb
• 関連するPDBエントリー: 1G73 3CM2
• 分子名称: Baculoviral IAP repeat-containing protein 4, ZINC ION, (3S,6S,7S,9aS)-6-{[(2S)-2-aminobutanoyl]amino}-N-(diphenylmethyl)-7-(hydroxymethyl)-5-oxooctahydro-1H-pyrrolo[1,2-a]azepine-3-carboxamide, ... (4 entities in total)
• 機能のキーワード: zinc-finger, apoptosis, cytoplasm, ligase, metal-binding, phosphoprotein, polymorphism, protease inhibitor, thiol protease inhibitor, ubl conjugation, ubl conjugation pathway
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: P98170
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 61918.66

構造登録者

Milani, M.,Mastrangelo, E.,Cossu, F. (登録日: 2008-03-20, 公開日: 2008-10-28, 最終更新日: 2023-08-30)

• 主引用文献: Mastrangelo, E.,Cossu, F.,Milani, M.,Sorrentino, G.,Lecis, D.,Delia, D.,Manzoni, L.,Drago, C.,Seneci, P.,Scolastico, C.,Rizzo, V.,Bolognesi, M.; Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principles.; J.Mol.Biol., 384:673-689, 2008; PubMed: 18851976; DOI: 10.1016/j.jmb.2008.09.064

実験手法

X-RAY DIFFRACTION (2.7 Å)