3CLD

Ligand binding domain of the glucocorticoid receptor complexed with fluticazone furoate

3CLD の概要

• エントリーDOI: 10.2210/pdb3cld/pdb
• 関連するPDBエントリー: 1m2z
• 分子名称: Glucocorticoid receptor, Tif2 coactivator motif, (6alpha,11alpha,14beta,16alpha,17alpha)-6,9-difluoro-17-{[(fluoromethyl)sulfanyl]carbonyl}-11-hydroxy-16-methyl-3-oxoan drosta-1,4-dien-17-yl furan-2-carboxylate, ... (4 entities in total)
• 機能のキーワード: glucocorticoid receptor, gr, nuclear receptor, alternative initiation, chromatin regulator, disease mutation, dna-binding, lipid-binding, metal-binding, nucleus, phosphoprotein, pseudohermaphroditism, steroid-binding, transcription, transcription regulation, zinc-finger
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cytoplasm. Isoform Beta: Nucleus: P04150
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 64006.35

構造登録者

Shewchuk, L.M.,McLay, I.,Stewart, E.,Biggadike, K.B.,Hassell, A.M.,Bledsoe, R.K. (登録日: 2008-03-18, 公開日: 2008-06-24, 最終更新日: 2023-08-30)

主引用文献

Biggadike, K.,Bledsoe, R.K.,Hassell, A.M.,Kirk, B.E.,McLay, I.M.,Shewchuk, L.M.,Stewart, E.L.
X-ray crystal structure of the novel enhanced-affinity glucocorticoid agonist fluticasone furoate in the glucocorticoid receptor-ligand binding domain.
J.Med.Chem., 51:3349-3352, 2008

PubMed Abstract: An X-ray crystal structure is reported for the novel enhanced-affinity glucocorticoid agonist fluticasone furoate (FF) in the ligand binding domain of the glucocorticoid receptor. Comparison of this structure with those of dexamethasone and fluticasone propionate shows the 17 alpha furoate ester to occupy more fully the lipophilic 17 alpha pocket on the receptor, which may account for the enhanced glucocorticoid receptor binding of FF.

PubMed: 18522385
DOI: 10.1021/jm800279t

実験手法

X-RAY DIFFRACTION (2.84 Å)