3CLD

Ligand binding domain of the glucocorticoid receptor complexed with fluticazone furoate

3CLD の概要

• エントリーDOI: 10.2210/pdb3cld/pdb
• 関連するPDBエントリー: 1m2z
• 分子名称: Glucocorticoid receptor, Tif2 coactivator motif, (6alpha,11alpha,14beta,16alpha,17alpha)-6,9-difluoro-17-{[(fluoromethyl)sulfanyl]carbonyl}-11-hydroxy-16-methyl-3-oxoan drosta-1,4-dien-17-yl furan-2-carboxylate, ... (4 entities in total)
• 機能のキーワード: glucocorticoid receptor, gr, nuclear receptor, alternative initiation, chromatin regulator, disease mutation, dna-binding, lipid-binding, metal-binding, nucleus, phosphoprotein, pseudohermaphroditism, steroid-binding, transcription, transcription regulation, zinc-finger
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cytoplasm. Isoform Beta: Nucleus: P04150
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 64006.35

構造登録者

Shewchuk, L.M.,McLay, I.,Stewart, E.,Biggadike, K.B.,Hassell, A.M.,Bledsoe, R.K. (登録日: 2008-03-18, 公開日: 2008-06-24, 最終更新日: 2023-08-30)

• 主引用文献: Biggadike, K.,Bledsoe, R.K.,Hassell, A.M.,Kirk, B.E.,McLay, I.M.,Shewchuk, L.M.,Stewart, E.L.; X-ray crystal structure of the novel enhanced-affinity glucocorticoid agonist fluticasone furoate in the glucocorticoid receptor-ligand binding domain.; J.Med.Chem., 51:3349-3352, 2008; PubMed: 18522385; DOI: 10.1021/jm800279t

実験手法

X-RAY DIFFRACTION (2.84 Å)