3CL9
Structure of bifunctional TcDHFR-TS in complex with MTX
Summary for 3CL9
Entry DOI | 10.2210/pdb3cl9/pdb |
Related | 2H2Q 3CLB |
Descriptor | Bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS), SULFATE ION, CHLORIDE ION, ... (8 entities in total) |
Functional Keywords | bifunctional enzyme in complex with nadp, mtx and dump, methyltransferase, multifunctional enzyme, nucleotide biosynthesis, one-carbon metabolism, oxidoreductase, transferase, oxidoreductase-transferase complex |
Biological source | Trypanosoma cruzi |
Total number of polymer chains | 1 |
Total formula weight | 60832.72 |
Authors | Schormann, N.,Senkovich, O.,Chattopadhyay, D. (deposition date: 2008-03-18, release date: 2009-01-06, Last modification date: 2023-08-30) |
Primary citation | Schormann, N.,Senkovich, O.,Walker, K.,Wright, D.L.,Anderson, A.C.,Rosowsky, A.,Ananthan, S.,Shinkre, B.,Velu, S.,Chattopadhyay, D. Structure-based approach to pharmacophore identification, in silico screening, and three-dimensional quantitative structure-activity relationship studies for inhibitors of Trypanosoma cruzi dihydrofolate reductase function. Proteins, 73:889-901, 2008 Cited by PubMed: 18536013DOI: 10.1002/prot.22115 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.3 Å) |
Structure validation
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