3CL9

Structure of bifunctional TcDHFR-TS in complex with MTX

3CL9 の概要

• エントリーDOI: 10.2210/pdb3cl9/pdb
• 関連するPDBエントリー: 2H2Q 3CLB
• 分子名称: Bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS), SULFATE ION, CHLORIDE ION, ... (8 entities in total)
• 機能のキーワード: bifunctional enzyme in complex with nadp, mtx and dump, methyltransferase, multifunctional enzyme, nucleotide biosynthesis, one-carbon metabolism, oxidoreductase, transferase, oxidoreductase-transferase complex
• 由来する生物種: Trypanosoma cruzi
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 60832.72

構造登録者

Schormann, N.,Senkovich, O.,Chattopadhyay, D. (登録日: 2008-03-18, 公開日: 2009-01-06, 最終更新日: 2023-08-30)

• 主引用文献: Schormann, N.,Senkovich, O.,Walker, K.,Wright, D.L.,Anderson, A.C.,Rosowsky, A.,Ananthan, S.,Shinkre, B.,Velu, S.,Chattopadhyay, D.; Structure-based approach to pharmacophore identification, in silico screening, and three-dimensional quantitative structure-activity relationship studies for inhibitors of Trypanosoma cruzi dihydrofolate reductase function.; Proteins, 73:889-901, 2008; PubMed: 18536013; DOI: 10.1002/prot.22115

実験手法

X-RAY DIFFRACTION (3.3 Å)